Mark D. Marsden, Ph.D.

Prior to joining the firm, Dr. Marsden conducted post-doctoral research at the Fred Hutchinson Cancer Research Center in Seattle investigating chromosomal regulatory elements of human serpin genes. Dr. Marsden earned his Ph.D. in the laboratory of Sir Dai Rees at the National Institute for Medical Research, Mill Hill, London.

Dr. Marsden joined the firm in 2007.

Additional Information

Representative Patents

U.S. 7,727,715: Global gene expression analysis of human bronchial epithelial cells exposed to cigarette smoke, smoke condensates, or components thereof

U.S. 7,700,542: Biodegradable cationic polymers

U.S. 7,674,903: Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof

U.S. 7,674,452: Polymer coating of cells

U.S. 7,663,024: P15 hairpin constructs and use

U.S. 7,662,565: Approaches to identify less harmful tobacco and tobacco products

U.S. 7,588,754: Biodegradable polyacetals and methods

European Patent 1687406: Nucleic acid detection method having increased sensitivity

Australian Patent 2004236714: Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen

Specializing In

Cases, Articles, Speeches & Seminars

Representative Matters

The Rockefeller University v. Ligand Pharmaceuticals, Inc. (S.D.N.Y. 2008-2009). Assay Technology related to Drug Development. Representing defendant in a technology license dispute relating to GlaxoSmithKline's Promacta-brand product. Obtained favorable settlement prior to expert discovery.

Articles

Marsden, M.D. and Fournier R.E.K.. Organization and expression of the human serpin gene cluster at 14q32.1. Frontiers in Bioscience, 10:1768-1778, 2005.

Namciu, S.J., Friedman, R.D., Marsden, M.D., Sarausad, L.M., Jasoni, C.L., Fournier, R.E.K.. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mammalian Genome. 15(3): 162-78, 2004.

Marsden, M.D. and Fournier, R.E.K.. Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1. Molecular & Cellular Biology. 23(10):3516-3526, 2003.

Rollini, P., Namciu, S.J., Marsden, M.D., Fournier, R.E.K. Identification and characterization of nuclear matrix-attachment regions in the human serpin gene cluster at 14q32.1. Nucleic Acids Research. 27(19):3779-91, 1999.

Adams, M.J., Reichel, M.B., King, I.A., Marsden, M.D., Greenwood, M.D., Thirlwell, H., Arnemann, J., Buxton, R.S., Ali, R.R.. Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens. Biochemical Journal. 329:165-74, 1998.

Greenwood, M.D., Marsden, M.D., Cowley, C.M., Sahota, V.K., Buxton, R.S.. Exon-intron organization of the human type 2 desmocollin gene (DSC2): desmocollin gene structure is closer to "classical" cadherins than to desmogleins. Genomics. 44(3):330-5, 1997.

Cowley C.M., Simrak, D., Marsden, M.D., King, I.A., Arnemann, J., Buxton, R.S.. A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes. Genomics. 42(2):208-16, 1997.

Marsden, M.D., Collins, J.E., Greenwood, M.D., Adams, M.J., Fleming, T.P., Magee, A.I., Buxton, R.S.. Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2). Gene. 186(2):237-47, 1997.

Marsden, M.D.. A molecular genetic analysis of the desmosomal cadherins. Doctoral thesis, University of London, 1995.

Buxton, R.S., Wheeler, G.N., Pidsley, S.C., Marsden, M.D., Adams, M.J., Jenkins, N.A., Gilbert, D.J., Copeland, N.G.. Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 21(3):510-6, 1994.

Sallenave, J.M., Marsden, M.D., Ryle, AP.. Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity. Biological Chemistry Hoppe-Seyler. 373(1):27-33, 1992.